Enhancement of rigidity in Parkinson's disease with activation.
Identifieur interne : 002473 ( Main/Exploration ); précédent : 002472; suivant : 002474Enhancement of rigidity in Parkinson's disease with activation.
Auteurs : Minna Hong [États-Unis] ; Joel S. Perlmutter ; Gammon M. Earhart [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Muscle Rigidity, Parkinson Disease.
- physiopathology : Muscle Rigidity, Muscle, Skeletal, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.
DOI: 10.1002/mds.21524
PubMed: 17443709
Affiliations:
- États-Unis
- Missouri (État)
- Saint-Louis (Missouri)
- Université Washington de Saint-Louis, École de médecine (Université Washington de Saint-Louis)
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Perlmutter</name></author><author><name sortKey="Earhart, Gammon M" sort="Earhart, Gammon M" uniqKey="Earhart G" first="Gammon M" last="Earhart">Gammon M. Earhart</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university" n="3">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university" n="3">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle Rigidity (epidemiology)</term><term>Muscle Rigidity (physiopathology)</term><term>Muscle, Skeletal (physiopathology)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Muscle Rigidity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle Rigidity</term><term>Muscle, Skeletal</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently not additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li></region><settlement><li>Saint-Louis (Missouri)</li></settlement><orgName><li>Université Washington de Saint-Louis</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name></noCountry><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Hong, Minna" sort="Hong, Minna" uniqKey="Hong M" first="Minna" last="Hong">Minna Hong</name></region><name sortKey="Earhart, Gammon M" sort="Earhart, Gammon M" uniqKey="Earhart G" first="Gammon M" last="Earhart">Gammon M. 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